Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug DevelopmentArticle Published on 2022-11-142022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] binding binding site Chemical chemotypes Comprehensive Consensus COVID19-NMR development drug drug design Drug discovery fragment fragment screening functional identify International Intervention Ligand NMR NMR spectroscopy novel performed predict protease Protein Proteins proteome protocol provide public health RNA genome SARS-CoV-2 SARS-CoV-2. Screening Space the SARS-CoV-2 Vaccines variant variants of concern was used [DOI] 10.1002/anie.202205858 PMC 바로가기
Humoral response to COVID-19 vaccination in MS patients on disease modifying therapy: Immune profiles and clinical outcomesArticle Published on 2022-11-012022-10-05 Journal: Multiple sclerosis and related disorders [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술, [키워드] administration age anti-CD20 anti-CD20 therapy Anti-SARS-CoV-2 S antibody Antibody Response Antibody titer appear B-cell CD20 cell count Clinical outcome Cohort collected Comprehensive COVID-19 COVID-19 infection COVID-19 vaccination death demographic demonstrated diagnosed with COVID-19 died disease Disease modifying therapy effective enrolled female FIVE Follow-up healthy control healthy controls humoral Humoral immunity Humoral response ICU care Immune profile immunoglobulins incidence increased risk investigation less longitudinal Lymphocyte count Multiple multiple sclerosis outcome Patient preventing infection profile reduced required Responder response to vaccination Result retrospective SARS-CoV-2 spike sclerosis serum severe disease significantly lower single-center study therapy Treatment vaccinated against COVID-19 vaccination Vaccine [DOI] 10.1016/j.msard.2022.104079 [Article Type] Article
Comprehensive analysis of pathways in Coronavirus 2019 (COVID-19) using an unsupervised machine learning methodResearch article Published on 2022-10-012022-10-05 Journal: Applied Soft Computing [Category] 바이오마커, 변종, 신약개발, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory syndrome Analysis approach artificial intelligence assist available data Bioinformatics analysis biological pathway Biomarkers Comprehensive comprehensive analysis coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pathology defined disease dominant effective Features first stage help host cell implementation introduced machine learning material Novel coronavirus pathway Pathway analysis Pathway enrichment analysis Pathways researcher SARS-CoV-2 selected Signaling target Treatment unsupervised learning WHO World Health Organization worldwide crisis [DOI] 10.1016/j.asoc.2022.109510 [Article Type] Research article
Optimization of COVID-19 prevention and control measures during the Beijing 2022 Winter Olympics: a model-based studyArticle Published on 2022-09-062022-11-15 Journal: Infectious Diseases of Poverty [Category] SARS, 치료기술, [키워드] acute respiratory syndrome assumed baseline levels Beijing Combination Comprehensive Contact coronavirus coronavirus disease COVID-19 COVID-19 transmission cumulative dynamic Dynamic model Epidemic evaluate the effect health monitoring Hospitalized Infection Intervention Isolation management measure medical resource Mutation nucleic acid optimization pandemic parameter predict Prevent Prevention and control Prevention and control measure provided pulse reached reducing reduction Research risk sensitivity analysis Spread The Beijing 2022 Winter Olympics. the epidemic Transmission Transmission dynamics virus transmission Winter [DOI] 10.1186/s40249-022-01019-2 PMC 바로가기
X-ray image based COVID-19 detection using evolutionary deep learning approachResearch article Published on 2022-09-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 변종, 치료기술, [키워드] Accuracy Algorithm approach automatically boundary Chest Chest X-ray images Classifier CNN complex Comprehensive Convolutional neural network coronavirus coronavirus disease COVID-19 COVID-19 disease deep learning Deep neuroevolution learning detect detectable develop diagnose effective help image classification IMPROVE K-nearest neighbor classifier labeling MONITOR radiological radiologist replaced significantly more time-consuming Trial X-ray [DOI] 10.1016/j.eswa.2022.116942 [Article Type] Research article
Updated Results of the COVID-19 in MS Global Data Sharing Initiative: Anti-CD20 and Other Risk Factors Associated With COVID-19 SeverityArticle Published on 2022-08-292022-11-15 Journal: Neurology® neuroimmunology & neuroinflammation [Category] 바이오마커, 진단, [키워드] 95% CI Acetate acute respiratory syndrome adjusted Admission age anti-CD20 artificial ventilation association Clinical characteristics Comprehensive coronavirus coronavirus disease country Course COVID-19 COVID-19 severity death Effects Factor Hospitalization Infection intensive care International Logistic regression Male sex medication multiple sclerosis Older age Other outcome Patient patients phenotype predicted Probability real-world data Result severe COVID-19 severity Sex therapy Ventilation were assessed with COVID-19 [DOI] 10.1212/NXI.0000000000200021 PMC 바로가기
Advancing Precision Vaccinology by Molecular and Genomic Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 in Germany, 20212021년 독일에서 중증 급성 호흡기 증후군 코로나바이러스 2의 분자 및 게놈 감시를 통한 정밀 백신학 발전Article Published on 2022-08-152022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 유전자 메커니즘, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Advancing Alpha variant analysis Analysis approach Beta collected complement Comprehensive contributed coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 dataset deceleration Delta wave Effectiveness effort estimate Evolution expansion facilitated Genetic genomic genomic sequencing Genomic surveillance Germany GISAID immune evasion in vitro incidence incidence estimation indicated Laboratory molecular molecular surveillance Multiple multiple mutations Mutation National neutralization assays observation period pathogen pathogen genomics Phylogenetic analysis powerful tool Precision Public public health Randomly respiratory resulting Robert Koch SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 genomic surveillance sequence sequenced sample Spread Surveillance the SARS-CoV-2 undergo vaccination Vaccination strategies Vaccination strategy Vaccine variant Variant of concern. variants of concern virus whole-genome sequencing [DOI] 10.1093/cid/ciac399 PMC 바로가기 [Article Type] Article
Acquired von Willebrand Syndrome and Desmopressin Resistance During Venovenous Extracorporeal Membrane Oxygenation in Patients With COVID-19: A Prospective Observational StudyObservational Study Published on 2022-08-012022-10-05 Journal: Critical Care Medicine [Category] 임상, [키워드] Acquired acute respiratory distress age analyses analysis Antigen ARDS benefit binding bleeding collagen Comorbidities Comprehensive correlated COVID-19 COVID-19 patient COVID-19-associated ARDS decrease desmopressin Effectiveness elevated Extracorporeal extracorporeal membrane oxygenation ICU incidence male measurement not affect parameter parameters Patient performed polyacrylamide gel Prospective resistance screening test severity sodium syndrome thrombosis treated Treatment undetectable variable von Willebrand factor [DOI] 10.1097/CCM.0000000000005467 PMC 바로가기 [Article Type] Observational Study
Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™SARS-COV-2 항바이러스 치료제 Paxlovid™의 적시 개발을 지원하는 Nirmatrelvir의 포괄적인 비임상 안전성 평가Article Published on 2022-08-012022-09-11 Journal: International journal of toxicology [Category] 치료제, [키워드] 3CL administration Antiviral Arrhythmias assessment blood pressure cardiovascular caused clinical development Clinical pathology coagulation time Comprehensive conducted COVID-19 COVID-19 patient COVID-19 patients death decrease decreases development dose Drug safety Effect Efficacy Endpoint enhancer enzyme functional heart rate high risk highest dose Hospitalization Increases increases in induce Infection locomotor male MPro nervous system Nirmatrelvir not affect pathology Paxlovid pharmacokinetic Potential produced profile protease RATs Replication respiratory rate Ritonavir Safety safety pharmacology SARS-CoV-2 SARS-CoV-2 virus Support Supporting target tested the SARS-CoV-2 virus toxicities Toxicity toxicology toxicology. transaminase transaminases Treatment treatment of COVID-19 were assessed [DOI] 10.1177/10915818221095489 PMC 바로가기 [Article Type] Article
Comprehensive Cytokine Profiling of Patients with COVID-19 Receiving Tocilizumab Therapy토실리주맙 치료를 받는 COVID-19 환자의 종합적인 사이토카인 프로파일링Article Published on 2022-07-192022-09-12 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 진단, [키워드] addition Administered administration Admission analyzed anti-cytokine anti-cytokine therapy Blood changes characterized circulating cytokine Clinical endpoints Cluster Comprehensive Concentration Coronavirus disease 2019 correlated COVID-19 criteria CSS cytokine cytokine profile Cytokine storm Cytokine storm syndrome Cytokines defined demonstrated disease severity Follow-up follow-up period G-CSF group hospitalized patient IL-10 IL-1ra IL-6 immune activation in both group increased mortality indication Inflammation interleukin Laboratory laboratory parameter multiple cytokines multiplex parameter pathophysiological mechanism Patient performed plasma Profiling Prognosis separated Severe case the patient to define Tocilizumab tocilizumab therapy tocilizumab. treatment with tocilizumab viral spread with COVID-19 [DOI] 10.3390/ijms23147937 PMC 바로가기 [Article Type] Article